Around 80% of fires in hyperbaric chambers occur due to the presence of "prohibited items" in the chamber. The National Fire Protection Association (NFPA)'s recommends that facilities conduct risk assessments for dressings and items that have not been deemed safe for use in the hyperbaric chamber. However, there are several obstacles that may prevent compliance. This topic clarifies what a "prohibited item" is and provides a practical approach to determine which specific patient care items may be safely allowed into the chamber.